Pneumonia and ACE inhibitors--and cough

Pneumonia and ACE inhibitors--and cough.

Angiotensin converting enzyme (ACE) inhibitors are widely used to treat heart failure and hypertension. They act through blocking the conversion of angiotensin I to angiotensin II; this inhibits the breakdown of bradykinin, which in turn lowers arteriole resistance and increases venous return. Many patients taking ACE inhibitors experience a persistent dry cough, which is thought to be caused b...

Iron supplementation inhibits cough associated with ACE inhibitors.

Dry cough is the most common limiting factor of ACE inhibitor (ACEI) use. Generation of NO, a proinflammatory substance on bronchial epithelial cells, is increased by ACEI. Using a randomized, double-blind, placebo-controlled trial, we tested the hypothesis that supplementing iron, an inhibitor of NO synthase, may reduce the cough associated with ACEI use. The subjects were 19 patients who had ...

ACE, ACE inhibitors, and other JNK.

The renin-angiotensin system (RAS) plays a pivotal role in the regulation of blood pressure, volume homeostasis, vascular function, and cell growth. In what is considered the classic RAS, renin is released from juxtaglomerular cells of the kidney into the circulation where it converts angiotensinogen from the liver to angiotensin I. Angiotensin I is subsequently hydrolyzed by a peptidyl dipepti...

ACE inhibitors and anaesthesia.

During the last decade, two angiotensin converting enzyme (ACE) inhibitors, captopril and enalapril, have become accepted into clinical practice and are regarded as effective treatments for hypertension and congestive cardiac failure.' A third agent, lisinopril, had recently become available and others are likely to be introduced in the near future. It is clear, therefore, that more patients, w...

eComment: Statins and ACE-inhibitors.